10.1038/s41419-022-05372-w 24 JiangX.StockwellB
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Besides that, in cancers that have already developed, bilirubin may also function to inhibit tumor progression while preserving normal cells
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These data do not indicate if transcript suppression was a direct result of AG-120 treatment or rather a second level consequence of mitochondrial injury, the known mechanism of AG-120 suggests the latter explanation is more likely
Oral bioavailability ranges from 1030% due to first-pass hepatic metabolism and gastric degradation, while subcutaneous injection achieves near-100% bioavailability with direct systemic distribution
